Human genetic history on the Tibetan Plateau in the past 5100 years-Reference-Cited by-同舟云学术

Human genetic history on the Tibetan Plateau in the past 5100 years

Published:2023-03-17 Issue:11 Volume:9 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Wang Hongru¹^ORCID,Yang Melinda A.¹²^ORCID,Wangdue Shargan³^ORCID,Lu Hongliang⁴⁵,Chen Honghai⁶,Li Linhui³,Dong Guanghui⁷,Tsring Tinley³,Yuan Haibing⁴⁵^ORCID,He Wei³^ORCID,Ding Manyu¹⁸,Wu Xiaohong⁹^ORCID,Li Shuai⁴⁵,Tashi Norbu³,Yang Tsho³,Yang Feng⁴⁵,Tong Yan³,Chen Zujun³,He Yuanhong⁴⁵^ORCID,Cao Peng¹,Dai Qingyan¹,Liu Feng¹,Feng Xiaotian¹,Wang Tianyi¹⁸^ORCID,Yang Ruowei¹,Ping Wanjing¹^ORCID,Zhang Zhaoxia¹,Gao Yang¹⁰¹¹^ORCID,Zhang Ming⁶,Wang Xiaoji¹¹,Zhang Chao¹¹^ORCID,Yuan Kai¹¹^ORCID,Ko Albert Min-Shan¹,Aldenderfer Mark¹²^ORCID,Gao Xing¹⁸^ORCID,Xu Shuhua¹⁰¹¹¹³¹⁴^ORCID,Fu Qiaomei¹⁸¹⁵^ORCID

Affiliation:

1. Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Center for Excellence in Life and Paleoenvironment, Chinese Academy of Sciences, Beijing 100044, China.

2. Department of Biology, University of Richmond, Richmond, VA 23173, USA.

3. Tibet Institute for Conservation and Research of Cultural Relics, Lhasa 850000, China.

4. School of Archaeology and Museology, Sichuan University, Chengdu 610064, China.

5. Center for Archaeological Science, Sichuan University, Chengdu 610064, China.

6. School of Cultural Heritage, Northwest University, Xi’an 710069, China.

7. Key Laboratory of Western China’s Environmental Systems (Ministry of Education), College of Earth and Environmental Sciences, Lanzhou University, Lanzhou 730000, China.

8. University of the Chinese Academy of Sciences, Beijing 100049, China.

9. School of Archaeology and Museology, Peking University, Beijing 100871, China.

10. State Key Laboratory of Genetic Engineering, Center for Evolutionary Biology, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200438, China.

11. Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

12. Department of Anthropology and Heritage Studies, University of California, Merced, Merced, CA 95343, USA.

13. Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

14. Human Phenome Institute, Zhangjiang Fudan International Innovation Center, and Ministry of Education Key Laboratory of Contemporary Anthropology, Fudan University, Shanghai 201203, China.

15. Shanghai Qi Zhi Institute, Shanghai 200232, China.

Abstract

Using genome-wide data of 89 ancient individuals dated to 5100 to 100 years before the present (B.P.) from 29 sites across the Tibetan Plateau, we found plateau-specific ancestry across plateau populations, with substantial genetic structure indicating high differentiation before 2500 B.P. Northeastern plateau populations rapidly showed admixture associated with millet farmers by 4700 B.P. in the Gonghe Basin. High genetic similarity on the southern and southwestern plateau showed population expansion along the Yarlung Tsangpo River since 3400 years ago. Central and southeastern plateau populations revealed extensive genetic admixture within the plateau historically, with substantial ancestry related to that found in southern and southwestern plateau populations. Over the past ~700 years, substantial gene flow from lowland East Asia further shaped the genetic landscape of present-day plateau populations. The high-altitude adaptive EPAS1 allele was found in plateau populations as early as in a 5100-year-old individual and showed a sharp increase over the past 2800 years.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

https://www.science.org/doi/pdf/10.1126/sciadv.add5582

Reference122 articles.

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3. Agriculture facilitated permanent human occupation of the Tibetan Plateau after 3600 B.P.

4. Permanent human occupation of the central Tibetan Plateau in the early Holocene

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