A cell-based screening method using an intracellular antibody for discovering small molecules targeting the translocation protein LMO2-Reference-Cited by-同舟云学术

A cell-based screening method using an intracellular antibody for discovering small molecules targeting the translocation protein LMO2

Published:2021-04-09 Issue:15 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Bery Nicolas¹^ORCID,Bataille Carole J.R.²^ORCID,Russell Angela²,Hayes Angela³^ORCID,Raynaud Florence³^ORCID,Milhas Sabine¹^ORCID,Anand Sneha¹^ORCID,Tulmin Hanna¹,Miller Ami¹^ORCID,Rabbitts Terence H.¹^ORCID

Affiliation:

1. Weatherall Institute of Molecular Medicine MRC Molecular Haematology Unit, University of Oxford John Radcliffe Hospital, Oxford OX3 9DS, UK.

2. University of Oxford Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, UK.

3. Institute of Cancer Research, 15 Cotswold Road, Sutton, London SM2 5NG, UK.

Abstract

A cell-based screening uses intracellular antibodies to select compounds targeting the chromosomal translocation protein LMO2.

Funder

Wellcome

Medical Research Council

Bloodwise

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference43 articles.

1. Intracellular antibodies and cancer: New technologies offer therapeutic opportunities

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3. Cancer cell killing by target antigen engagement with engineered complementary intracellular antibody single domains fused to pro-caspase3

4. Intracellular antibody-caspase-mediated cell killing: An approach for application in cancer therapy

5. A potent KRAS macromolecule degrader specifically targeting tumours with mutant KRAS

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