Vascular endothelium–targeted Sirt7 gene therapy rejuvenates blood vessels and extends life span in a Hutchinson-Gilford progeria model-Reference-Cited by-同舟云学术

Vascular endothelium–targeted Sirt7 gene therapy rejuvenates blood vessels and extends life span in a Hutchinson-Gilford progeria model

Published:2020-02-21 Issue:8 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Sun Shimin¹²³^ORCID,Qin Weifeng²³^ORCID,Tang Xiaolong²³^ORCID,Meng Yuan²³^ORCID,Hu Wenjing²,Zhang Shuju²³,Qian Minxian²³⁴^ORCID,Liu Zuojun²³⁴,Cao Xinyue²³⁴,Pang Qiuxiang¹,Zhao Bosheng¹,Wang Zimei³⁴^ORCID,Zhou Zhongjun⁵^ORCID,Liu Baohua²³⁴⁶^ORCID

Affiliation:

1. Anti-aging & Regenerative Medicine Research Institution, School of Life Sciences, Shandong University of Technology, Zibo 255049, China.

2. National Engineering Research Center for Biotechnology (Shenzhen), Carson International Cancer Center, Medical Research Center, Shenzhen University Health Science Center, Shenzhen, China.

3. Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, Shenzhen University Health Science Center, Shenzhen, China.

4. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen 518055, China.

5. School of Biological Sciences, Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.

6. Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen 518055, China.

Abstract

Aged blood vessels accelerate systemic aging; SIRT7 gene therapy rejuvenates blood vessels and promotes longevity in aging model.

Funder

National Natural Science Foundation of China

Shenzhen Science and Technology Innovation Commission

National key R&D program of China

Science and Technology Program of Guangdong Province

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference43 articles.

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