Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies-Reference-Cited by-同舟云学术

Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies

Published:2021-11-26 Issue:48 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Linsenmeier Luise¹^ORCID,Mohammadi Behnam¹^ORCID,Shafiq Mohsin¹^ORCID,Frontzek Karl²^ORCID,Bär Julia³⁴,Shrivastava Amulya N.⁵^ORCID,Damme Markus⁶,Song Feizhi¹,Schwarz Alexander⁷^ORCID,Da Vela Stefano⁸^ORCID,Massignan Tania⁹^ORCID,Jung Sebastian¹⁰^ORCID,Correia Angela¹¹,Schmitz Matthias¹¹^ORCID,Puig Berta¹²^ORCID,Hornemann Simone²^ORCID,Zerr Inga¹¹,Tatzelt Jörg¹⁰¹³^ORCID,Biasini Emiliano⁹,Saftig Paul⁶,Schweizer Michaela⁴,Svergun Dmitri⁸^ORCID,Amin Ladan¹⁴^ORCID,Mazzola Federica¹⁵,Varani Luca¹⁵^ORCID,Thapa Simrika¹⁶,Gilch Sabine¹⁶,Schätzl Hermann¹⁶^ORCID,Harris David A.¹⁴^ORCID,Triller Antoine⁵,Mikhaylova Marina³⁴,Aguzzi Adriano²^ORCID,Altmeppen Hermann C.¹^ORCID,Glatzel Markus¹^ORCID

Affiliation:

1. Institute of Neuropathology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.

2. Institute of Neuropathology, University of Zurich, Zürich, Switzerland.

3. Institute of Biology, Humboldt-Universität zu Berlin, Berlin, Germany.

4. Center for Molecular Neurobiology Hamburg (ZMNH), UKE, Hamburg, Germany.

5. École Normale Supérieure, Institut de Biologie de l’ENS (IBENS), INSERM, CNRS, PSL Research University, Paris, France.

6. Institute of Biochemistry, Christian Albrechts University, Kiel, Germany.

7. Institute of Nanostructure and Solid State Physics, Universität Hamburg, Hamburg, Germany.

8. European Molecular Biology Laboratory (EMBL), Hamburg, Germany.

9. Dulbecco Telethon Laboratory of Prions and Amyloids, CIBIO, University of Trento, Trento, Italy.

10. Department Biochemistry of Neurodegenerative Diseases, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, Germany.

11. Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.

12. Department of Neurology, Experimental Research in Stroke and Inflammation, UKE, Hamburg, Germany.

13. Cluster of Excellence RESOLV, Bochum, Germany.

14. Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA.

15. Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.

16. Calgary Prion Research Unit, University of Calgary, Calgary, Alberta, Canada.

Abstract

Ligand-stimulated enzymatic release or cellular degradation of PrP may interfere with neurodegeneration-associated toxicity.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference134 articles.

1. Games Played by Rogue Proteins in Prion Disorders and Alzheimer's Disease

2. Propagation of Protein Aggregation in Neurodegenerative Diseases

3. Alzheimer's and prion diseases: distinct pathologies, common proteolytic denominators

4. Prion protein in Alzheimer's pathogenesis: a hot and controversial issue

5. Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

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