Estimation of the in vivo neutralization potency of eCD4Ig and conditions for AAV-mediated production for SHIV long-term remission-Reference-Cited by-同舟云学术

Estimation of the in vivo neutralization potency of eCD4Ig and conditions for AAV-mediated production for SHIV long-term remission

Published:2022-01-14 Issue:2 Volume:8 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Goyal Ashish¹^ORCID,Gardner Matthew²^ORCID,Mayer Bryan T.¹^ORCID,Jerome Keith R.¹³^ORCID,Farzan Michael⁴^ORCID,Schiffer Joshua T.¹⁵⁶^ORCID,Cardozo-Ojeda E. Fabian¹^ORCID

Affiliation:

1. Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

2. Department of Medicine, Emory University, Atlanta, GA, USA.

3. Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.

4. Department of Immunology and Microbiology, Scripps Research Institute, Florida Campus, Jupiter, FL, USA.

5. Department of Medicine, University of Washington, Seattle, WA, USA.

6. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Abstract

eCD4Ig has an in vivo IC 50 of 25 μg/ml, and it may induce ART-free virus control if produced continually at 10 5 μg/day or more.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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