Computer simulations explain mutation-induced effects on the DNA editing by adenine base editors-Reference-Cited by-同舟云学术

登录注册会员服务联系我们

Computer simulations explain mutation-induced effects on the DNA editing by adenine base editors

Published:2020-03-06 Issue:10 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Rallapalli Kartik L.¹^ORCID,Komor Alexis C.¹^ORCID,Paesani Francesco¹²³^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.

2. Materials Science and Engineering, University of California, San Diego, La Jolla, CA 92093, USA.

3. San Diego Supercomputer Center, University of California, San Diego, La Jolla, CA 92093, USA.

Abstract

We uncovered structural and functional changes induced by mutations that dictate the DNA editing activity of ABE enzymes.

Funder

National Science Foundation

National Institutes of Health

University of California San Diego

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference45 articles.

1. Base editing: precision chemistry on the genome and transcriptome of living cells

2. Editing the Genome Without Double-Stranded DNA Breaks

3. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

4. Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

5. Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

Cited by 21 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. CHIMERA_NA: A Customizable Mutagenesis Tool for Structural Manipulations in Nucleic Acids and Their Complexes;ACS Omega;2024-09-13

2. MutaT7^GDE: A Single Chimera for the Targeted, Balanced, Efficient, and Processive Installation of All Possible Transition Mutations In Vivo;ACS Synthetic Biology;2024-08-27

3. Directed-evolution mutations enhance DNA-binding affinity and protein stability of the adenine base editor ABE8e;Cellular and Molecular Life Sciences;2024-06-14

4. Expanded palette of RNA base editors for comprehensive RBP-RNA interactome studies;Nature Communications;2024-01-29

5. Evolution of genome editing technologies;CRISPRized Horticulture Crops;2024

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号京ICP备18003416号-3