Intracellular delivery of Parkin rescues neurons from accumulation of damaged mitochondria and pathological α-synuclein-Reference-Cited by-同舟云学术

Intracellular delivery of Parkin rescues neurons from accumulation of damaged mitochondria and pathological α-synuclein

Published:2020-05 Issue:18 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Chung Eunna¹^ORCID,Choi Youngsil¹^ORCID,Park Jiae¹^ORCID,Nah Wonheum¹^ORCID,Park Jaehyung¹^ORCID,Jung Yukdong¹^ORCID,Lee Joonno¹^ORCID,Lee Hyunji¹^ORCID,Park Soyoung¹,Hwang Sunyoung¹^ORCID,Kim Seongcheol¹^ORCID,Lee Jongseok¹^ORCID,Min Dongjae¹^ORCID,Jo Junghwan¹^ORCID,Kang Shinyoung¹^ORCID,Jung Minyong¹,Lee Phil Hyu²^ORCID,Ruley H. Earl³,Jo Daewoong¹^ORCID

Affiliation:

1. Cellivery R&D Institute, Cellivery Therapeutics Inc., Seoul 03929, Korea.

2. Department of Neurology, Yonsei University College of Medicine, Seoul 120-752, Korea.

3. Department of Pathology, Microbiology & Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

Abstract

Cell-permeable Parkin ameliorates Parkinson’s disease-like phenotypes induced by mitochondrial poisons and aggregated α-synuclein.

Funder

Michael J. Fox Foundation for Parkinson’s Research

Ministry of Health and Welfare

Publisher

American Association for the Advancement of Science (AAAS)

Subject