Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101 complex reveals molecular mechanism of GPCR activation-Reference-Cited by-同舟云学术

Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101 complex reveals molecular mechanism of GPCR activation

Published:2021-08-27 Issue:35 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Rathinaswamy Manoj K.¹^ORCID,Dalwadi Udit²,Fleming Kaelin D.¹^ORCID,Adams Carson³⁴,Stariha Jordan T. B.¹^ORCID,Pardon Els⁵⁶^ORCID,Baek Minkyung³⁴^ORCID,Vadas Oscar⁷^ORCID,DiMaio Frank³⁴^ORCID,Steyaert Jan⁵⁶^ORCID,Hansen Scott D.⁸^ORCID,Yip Calvin K.²^ORCID,Burke John E.¹²^ORCID

Affiliation:

1. Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada.

2. Life Sciences Institute, Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, British Columbia, Canada.

3. Department of Biochemistry, University of Washington, Seattle, WA, USA.

4. Institute for Protein Design, University of Washington, Seattle, WA, USA.

5. Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium.

6. VIB-VUB Center for Structural Biology, VIB, Brussels, Belgium.

7. Department of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland.

8. Department of Chemistry and Biochemistry, University of Oregon, Eugene, OR, USA.

Abstract

The structure of class IB PI3K (p110γ-p101) reveals mechanism of GPCR activation and differences from class IA PI3Ks.

Funder

National Institutes of Health

Cancer Research Society

Canadian Institutes of Health Research

Natural Sciences and Engineering Research Council of Canada

Michael Smith Foundation for Health Research

National Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference69 articles.

1. The PI3K Pathway in Human Disease

2. Synergy in activating class I PI3Ks

3. p84, a New Gβγ-Activated Regulatory Subunit of the Type IB Phosphoinositide 3-Kinase p110γ

4. The Gβγ Sensitivity of a PI3K Is Dependent upon a Tightly Associated Adaptor, p101

5. Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells

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