SMARCAD1-mediated active replication fork stability maintains genome integrity

Author:

Lo Calvin Shun Yu1ORCID,van Toorn Marvin12,Gaggioli Vincent1ORCID,Paes Dias Mariana3ORCID,Zhu Yifan1,Manolika Eleni Maria1,Zhao Wei1,van der Does Marit1ORCID,Mukherjee Chirantani1,G. S. C. Souto Gonçalves João4ORCID,van Royen Martin E.5ORCID,French Pim J.6ORCID,Demmers Jeroen7ORCID,Smal Ihor1ORCID,Lans Hannes1ORCID,Wheeler David8ORCID,Jonkers Jos3ORCID,Chaudhuri Arnab Ray1,Marteijn Jurgen A.12ORCID,Taneja Nitika1ORCID

Affiliation:

1. Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3000 CA Rotterdam, Netherlands.

2. Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3000 CA Rotterdam, Netherlands.

3. Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands.

4. Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

5. Department of Pathology, Cancer Treatment Screening Facility (CTSF), Erasmus Optical Imaging Centre (OIC), Erasmus University Medical Center, Wytemaweg 80, 3015 CN Rotterdam, Netherlands.

6. Department of Neurology and Cancer Treatment Screening Facility (CTSF), Erasmus University Medical Center, Erasmus MC Cancer Institute, Rotterdam, Netherlands.

7. Proteomics Center and Department of Biochemistry, Erasmus University Medical Center, Wytemaweg 80, 3015 CN Rotterdam, Netherlands.

8. Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

The interplay of SMARCAD1-mediated active fork and BRCA1-mediated stalled fork stability pathways maintains genome integrity.

Funder

Daniel den Hoed Stiching Young Scientific Talent grant

Oncode Institute partly financed by the Dutch Cancer Society

Dutch Cancer Society funded grant

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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