Replication fork reversal triggers fork degradation in BRCA2-defective cells-Reference-Cited by-同舟云学术

Replication fork reversal triggers fork degradation in BRCA2-defective cells

Published:2017-10-16 Issue:1 Volume:8 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Mijic Sofija,Zellweger Ralph,Chappidi Nagaraja,Berti Matteo,Jacobs Kurt,Mutreja Karun,Ursich Sebastian,Ray Chaudhuri Arnab,Nussenzweig Andre,Janscak Pavel,Lopes Massimo

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/s41467-017-01164-5.pdf

Reference45 articles.

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2. Thorslund, T. et al. The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA. Nat. Struct. Mol. Biol. 17, 1263–1265 (2010).

3. Lord, C. J. & Ashworth, A. Mechanisms of resistance to therapies targeting BRCA-mutant cancers. Nat. Med. 19, 1381–1388 (2013).

4. Schlacher, K. et al. Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11. Cell 145, 529–542 (2011).

5. Schlacher, K., Wu, H. & Jasin, M. A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2. Cancer Cell 22, 106–116 (2012).

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