Sulfated polysaccharide directs therapeutic angiogenesis via endogenous VEGF secretion of macrophages

Author:

Yu Yuanman1ORCID,Dai Kai1,Gao Zehua2,Tang Wei3,Shen Tong2,Yuan Yuan2,Wang Jing1ORCID,Liu Changsheng2ORCID

Affiliation:

1. The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China.

2. Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, P. R. China.

3. Shenzhen Key Laboratory of Nanobiomechanics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P. R. China.

Abstract

A synthetic sulfated chitosan induces macrophage-mediated functional angiogenesis in ischemia without an aid of exogenous GFs.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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