MAIA, Fc receptor–like 3, supersedes JUNO as IZUMO1 receptor during human fertilization-Reference-Cited by-同舟云学术

MAIA, Fc receptor–like 3, supersedes JUNO as IZUMO1 receptor during human fertilization

Published:2022-09-09 Issue:36 Volume:8 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Vondrakova Jana¹^ORCID,Frolikova Michaela¹^ORCID,Ded Lukas¹^ORCID,Cerny Jiri²^ORCID,Postlerova Pavla¹³^ORCID,Palenikova Veronika¹,Simonik Ondrej¹^ORCID,Nahacka Zuzana⁴,Basus Krystof¹^ORCID,Valaskova Eliska¹^ORCID,Machan Radek⁵^ORCID,Pacey Allan⁶^ORCID,Holubcova Zuzana⁷⁸^ORCID,Koubek Pavel⁹,Ezrova Zuzana⁴^ORCID,Park Soojin¹⁰^ORCID,Liu Ruiwu¹¹,Partha Raghavendran¹²^ORCID,Clark Nathan¹³^ORCID,Neuzil Jiri⁴¹⁴,Ikawa Masahito¹⁰^ORCID,Erickson Kent¹⁵^ORCID,Lam Kit S.¹¹^ORCID,Moore Harry¹⁶^ORCID,Komrskova Katerina¹¹⁷^ORCID

Affiliation:

1. Laboratory of Reproductive Biology, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.

2. Laboratory of Structural Bioinformatics of Proteins, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.

3. Department of Veterinary Sciences, Faculty of Agrobiology, Food, and Natural Resources, Czech University of Life Sciences Prague, Kamycka 129, 165 00 Prague, Czech Republic.

4. Laboratory of Molecular Therapy, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.

5. Imaging Methods Core Facility at BIOCEV, Faculty of Science, Charles University, Prumyslova 595, 252 50 Vestec, Czech Republic.

6. Department of Oncology and Metabolism, University of Sheffield, Medical School, Sheffield S10 2RX, UK.

7. Reprofit International, Clinic of Reproductive Medicine, Brno, Czech Republic.

8. Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

9. ProCrea Swiss IVF Center, Prague, Czech Republic.

10. Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.

11. Department of Biochemistry and Molecular Medicine, University of California, Davis, School of Medicine, Davis, CA, USA.

12. Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.

13. Department of Human Genetics, University of Utah, Salt Lake City, UT, USA.

14. School of Pharmacy and Medical Science, Griffith University, Parklands Avenue, Southport, Qld 4222, Australia.

15. Department of Cell Biology and Human Anatomy, University of California, Davis, School of Medicine, Davis, CA, USA.

16. Centre for Stem Cell Biology, University of Sheffield, Sheffield S10 2TN, UK.

17. Department of Zoology, Faculty of Science, Charles University, Vinicna 7, 128 44 Prague, Czech Republic.

Abstract

Gamete fusion is a critical event of mammalian fertilization. A random one-bead one-compound combinatorial peptide library represented synthetic human egg mimics and identified a previously unidentified ligand as Fc receptor–like 3, named MAIA after the mythological goddess intertwined with JUNO. This immunoglobulin super family receptor was expressed on humanoolemmaand played a major role during sperm-egg adhesion and fusion. MAIA forms a highly stable interaction with the known IZUMO1/JUNO sperm-egg complex, permitting specific gamete fusion. The complexity of the MAIA isotype may offer a cryptic sexual selection mechanism to avoid genetic incompatibility and achieve favorable fitness outcomes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference65 articles.

1. Sperm-Egg Fusion: A Molecular Enigma of Mammalian Reproduction

2. The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs

3. Juno is the egg Izumo receptor and is essential for mammalian fertilization

4. Structure of IZUMO1–JUNO reveals sperm–oocyte recognition during mammalian fertilization

5. Severely Reduced Female Fertility in CD9-Deficient Mice

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