Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank-Reference-Cited by-同舟云学术

Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank

Published:2019-08-02 Issue:8 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Wang Huanwei¹^ORCID,Zhang Futao¹,Zeng Jian¹^ORCID,Wu Yang¹^ORCID,Kemper Kathryn E.¹^ORCID,Xue Angli¹^ORCID,Zhang Min¹^ORCID,Powell Joseph E.¹²³,Goddard Michael E.⁴⁵,Wray Naomi R.¹⁶^ORCID,Visscher Peter M.¹⁶,McRae Allan F.¹^ORCID,Yang Jian¹⁷^ORCID

Affiliation:

1. Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.

2. Garvan-Weizmann Centre for Cellular Genomics, Garvan Institute for Medical Research, Sydney, New South Wales 2010, Australia.

3. Faculty of Medicine, University of New South Wales, Sydney, New South Wales 2052, Australia.

4. Faculty of Veterinary and Agricultural Science, University of Melbourne, Parkville, Victoria, Australia.

5. Biosciences Research Division, Department of Economic Development, Jobs, Transport and Resources, Bundoora, Victoria, Australia.

6. Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia.

7. Institute for Advanced Research, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.

Abstract

We show that genotype-by-environment interaction can be inferred from an analysis without environmental data in a large sample.

Funder

Sylvia and Charles Viertel Charitable Foundation

Australian Research Council

Australian national health and medical research council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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