Inactivation-mimicking block of the epithelial calcium channel TRPV6-Reference-Cited by-同舟云学术

Inactivation-mimicking block of the epithelial calcium channel TRPV6

Published:2020-11-27 Issue:48 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Bhardwaj Rajesh¹^ORCID,Lindinger Sonja²^ORCID,Neuberger Arthur³^ORCID,Nadezhdin Kirill D.³,Singh Appu K.³⁴,Cunha Micael R.⁵^ORCID,Derler Isabella²^ORCID,Gyimesi Gergely¹^ORCID,Reymond Jean-Louis⁵^ORCID,Hediger Matthias A.¹^ORCID,Romanin Christoph²^ORCID,Sobolevsky Alexander I.³^ORCID

Affiliation:

1. Department of Nephrology and Hypertension and Department of Biomedical Research, University of Bern, Inselspital, Freiburgstrasse 15, CH-3010 Bern, Switzerland.

2. Institute of Biophysics, Johannes Kepler University Linz, Gruberstrasse 40, 4020 Linz, Austria.

3. Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, NY 10032, USA.

4. Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India.

5. Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland.

Abstract

Small-molecule piperazine derivatives mimic inactivation by calmodulin to selectively and potently block TRPV6 channels.

Funder

NIH Clinical Center

NSF Office of the Director

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference62 articles.

1. TRP channels as cellular sensors

2. Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine

3. M. V. Yelshanskaya K. D. Nadezhdin M. G. Kurnikova A. I. Sobolevsky Structure and function of the calcium-selective TRP channel TRPV6. J. Physiol. https://doi.org/10.1113/JP279024 (2020).

4. Marked Disturbance of Calcium Homeostasis in Mice With Targeted Disruption of the Trpv6 Calcium Channel Gene

5. Calcium Channel TRPV6 Is Involved in Murine Maternal-Fetal Calcium Transport

Cited by 26 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Dynamic molecular portraits of ion-conducting pores characterize functional states of TRPV channels;Communications Chemistry;2024-06-01

2. Advances in TRPV6 inhibitors for tumors by targeted therapies: Macromolecular proteins, synthetic small molecule compounds, and natural compounds;European Journal of Medicinal Chemistry;2024-04

3. Enhancement of intestinal calcium transport by short-chain fatty acids: roles of Na⁺/H⁺ exchanger 3 and transient receptor potential vanilloid subfamily 6;American Journal of Physiology-Cell Physiology;2024-02-01

4. Bidirectional Allosteric Coupling between PIP2 Binding and the Pore of the Oncochannel TRPV6;International Journal of Molecular Sciences;2024-01-03

5. Molecular pharmacology of the onco-TRP channel TRPV6;Channels;2023-10-15