Enhancement of intestinal calcium transport by short-chain fatty acids: roles of Na<sup>+</sup>/H<sup>+</sup> exchanger 3 and transient receptor potential vanilloid subfamily 6-Reference-Cited by-同舟云学术

Enhancement of intestinal calcium transport by short-chain fatty acids: roles of Na⁺/H⁺ exchanger 3 and transient receptor potential vanilloid subfamily 6

Published:2024-02-01 Issue:2 Volume:326 Page:C317-C330
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Thammayon Nithipak¹²³,Wongdee Kannikar¹⁴,Teerapornpuntakit Jarinthorn¹⁵,Panmanee Jiraporn⁶,Chanpaisaeng Krittikan¹⁷,Charoensetakul Netnapa⁷,Srimongkolpithak Nitipol⁷,Suntornsaratoon Panan¹²,Charoenphandhu Narattaphol¹²⁸⁹^ORCID

Affiliation:

1. Center of Calcium and Bone Research (COCAB), Faculty of Science, Mahidol University, Bangkok, Thailand

2. Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand

3. Graduate Program in Molecular Medicine, Faculty of Science, Mahidol University, Bangkok, Thailand

4. Faculty of Allied Health Sciences, Burapha University, Chonburi, Thailand

5. Department of Physiology, Faculty of Medical Science, Naresuan University, Phitsanulok, Thailand

6. Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand

7. National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathum Thani, Thailand

8. Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand

9. The Academy of Science, The Royal Society of Thailand, Bangkok, Thailand

Abstract

Organic molecules in the intestinal lumen, e.g., glucose and short-chain fatty acids (SCFAs), the latter of which are normally produced by microfloral fermentation, can stimulate calcium absorption dependent on transient receptor potential vanilloid subfamily 6 (TRPV6) and Na+/H+ exchanger 3 (NHE3). A selective TRPV6 inhibitor synthesized and demonstrated by in silico docking and molecular dynamics to specifically bind to the pore domain of TRPV6 was used to confirm a significant contribution of this channel. Our findings corroborate physiological significance of nutrients and SCFAs in enhancing calcium absorption.

Funder

Mahidol University

National Research Council of Thailand

Thailand Research Fund

Burapha University and Thailand Science Research and Innovation

Publisher

American Physiological Society

Subject

Cell Biology,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00330.2023

Reference61 articles.

1. Intestinal Calcium Absorption

2. Calcium Absorption Across Epithelia

3. Alternative perspective on intestinal calcium absorption: proposed complementary actions of Cav1.3 and TRPV6

4. The Na+/H+ exchanger isoform 3 is required for active paracellular and transcellular Ca2+ transport across murine cecum

5. Short-chain fatty acids enhance diffusional Ca transport in the epithelium of the rat cecum and colon