A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling-Reference-Cited by-同舟云学术

A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling

Published:2019-08-02 Issue:8 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Nguyen Duc-Huy T.¹^ORCID,Lee Esak²³^ORCID,Alimperti Styliani²³,Norgard Robert J.⁴^ORCID,Wong Alec²,Lee Jake June-Koo⁵^ORCID,Eyckmans Jeroen²³^ORCID,Stanger Ben Z.⁴^ORCID,Chen Christopher S.¹²³^ORCID

Affiliation:

1. Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

2. Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.

3. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

4. Division of Gastroenterology, Department of Medicine and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

5. Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.

Abstract

3D biomimetic pancreatic cancer on a chip reveals endothelial ablation via activin-ALK7, a mechanism for tumor hypovascularity.

Funder

National Institutes of Health

National Center for Advancing Translational Sciences

Lymphatic Education and Research Network

Harvard Ludwig Center

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary