Multicomponent reaction–derived covalent inhibitor space-Reference-Cited by-同舟云学术

Multicomponent reaction–derived covalent inhibitor space

Published:2021-02-05 Issue:6 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Sutanto Fandi¹^ORCID,Shaabani Shabnam¹^ORCID,Neochoritis Constantinos G.²^ORCID,Zarganes-Tzitzikas Tryfon¹^ORCID,Patil Pravin¹^ORCID,Ghonchepour Ehsan¹^ORCID,Dömling Alexander¹^ORCID

Affiliation:

1. Department of Drug Design, University of Groningen, A. Deusinglaan 1, 9700 AD Groningen, The Netherlands.

2. Department of Chemistry, University of Crete, 700 13 Heraklion, Greece.

Abstract

Electrophiles are used in covalent drug discovery and synthesized from electrophilic building blocks diversified by MCRs.

Funder

NIH Office of the Director

Horizon 2020 Framework Programme

KWF Kankerbestrijding

Indonesian Endowment Fund for Education

QNRF

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference77 articles.

1. Following the Lead from Nature with Covalent Inhibitors

2. Enzymes as a special class of therapeutic target: clinical drugs and modes of action

3. Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase

4. The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

5. Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands

Cited by 32 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. One-pot three-component synthesis of 2,4-dimethoxy-5,8,9,10-tetrahydropyrimido[4,5-b]quinolinone derivatives along with in silico and in vitro investigation of their antimalarial activity;Journal of Molecular Structure;2025-02

2. A new strategy for immobilization of copper on the Fe3O4@EDTA nanocomposite and its efficient catalytic applications in reduction and one-pot reductive acetylation of nitroarenes and also N-acetylation of arylamines;Heliyon;2024-08

3. An ecofriendly and efficient approach for three-component synthesis of benzothiazoles: research on catalytic application of Fe3O4@DOP-Amide/Imid-CuCl2 nanocomposite;Research on Chemical Intermediates;2024-07-20

4. Design of a Lead-Like Cysteine-Targeting Covalent Library and the Identification of Hits to Cys55 of Bfl-1;Journal of Medicinal Chemistry;2024-06-25

5. One‐Pot Three‐Component Construction of 2,4‐Diarylbenzo[4,5] thieno[3,2‐d] pyrimidines Using Elemental Sulfur as a Sulfur Source;ChemistrySelect;2024-06-18