Design of a Lead-Like Cysteine-Targeting Covalent Library and the Identification of Hits to Cys55 of Bfl-1-Reference-Cited by-同舟云学术

Design of a Lead-Like Cysteine-Targeting Covalent Library and the Identification of Hits to Cys55 of Bfl-1

Published:2024-06-25 Issue:13 Volume:67 Page:11209-11225
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lucas Simon C. C.¹^ORCID,Milbradt Alexander G.²,Blackwell J. Henry¹,Bonomo Silvia¹,Brierley Andrew³,Cassar Doyle J.⁴^ORCID,Freeman Jared⁵,Hadfield Thomas E.¹,Morrill Lucas A.⁶,Riemens Rick⁷,Sarda Sunil³,Schiesser Stefan⁸^ORCID,Wiktelius Daniel⁹^ORCID,Ahmed Samiyah¹⁰,Bostock Mark J.²,Börjesson Ulf¹¹,De Fusco Claudia¹^ORCID,Guerot Carine⁴,Hargreaves David²,Hewitt Sarah²,Lamb Michelle L.⁶^ORCID,Su Nancy¹²,Whatling Ryan²,Wheeler Matthew²^ORCID,Kettle Jason G.⁴^ORCID

Affiliation:

1. Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Cambridge CB2 0AA, U.K.

2. Mechanistic and Structural Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge CB2 0AA, U.K.

3. Compound Synthesis and Management, Discovery Sciences, R&D, AstraZeneca, Cambridge CB2 0AA, U.K.

4. Medicinal Chemistry, Oncology R&D, AstraZeneca, Cambridge CB2 0AA, U.K.

5. Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolic Disorders (CVRM), Biopharmaceuticals R&D, AstraZeneca, Gothenburg, SE-43183, Sweden

6. Medicinal Chemistry, Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States

7. Medicinal Chemistry, Oncology R&D, Acerta B. V., a Part of the AstraZeneca Group, Oss 5349, The Netherlands

8. Medicinal Chemistry, Research and Early Development, Respiratory and Immunology (R&I), Biopharmaceuticals R&D, AstraZeneca, Gothenburg, SE-43183, Sweden

9. Compound Synthesis and Management, Discovery Sciences, R&D, AstraZeneca, Gothenburg, SE-43183, Sweden

10. Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge CB2 0AA, U.K.

11. Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Gothenburg, SE-43183, Sweden

12. Mechanistic and Structural Biology, Discovery Sciences, R&D, AstraZeneca, Waltham, Massachusetts 02451, United States

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00781

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