Multiregional profiling of the brain transmembrane proteome uncovers novel regulators of depression

Author:

Li Shanshan1ORCID,Luo Huoqing23ORCID,Lou Ronghui123ORCID,Tian Cuiping1,Miao Chen1,Xia Lisha123,Pan Chen1,Duan Xiaoxiao1,Dang Ting123ORCID,Li Hui1,Fan Chengyu2,Tang Pan123ORCID,Zhang Zhuangzhuang123ORCID,Liu Yan1ORCID,Li Yunxia4ORCID,Xu Fei12ORCID,Zhang Yaoyang4ORCID,Zhong Guisheng12ORCID,Hu Ji25ORCID,Shui Wenqing12ORCID

Affiliation:

1. iHuman Institute, ShanghaiTech University, Shanghai 201210, China.

2. School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.

3. University of Chinese Academy of Sciences, Beijing 100049, China.

4. Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.

5. CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China.

Abstract

In-depth profiling of transmembrane proteins in the brain leads to the identification of GPCR regulators in a disease model.

Funder

National Program on Key Basic Research Project of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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