Novel enzymatic cross-linking–based hydrogel nanofilm caging system on pancreatic β cell spheroid for long-term blood glucose regulation-Reference-Cited by-同舟云学术

Novel enzymatic cross-linking–based hydrogel nanofilm caging system on pancreatic β cell spheroid for long-term blood glucose regulation

Published:2021-06-25 Issue:26 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Kim Minji¹^ORCID,Kim Hyunbum¹^ORCID,Lee Young-sun¹^ORCID,Lee Sangjun²,Kim Seong-Eun³,Lee Uk-Jae¹^ORCID,Jung Sungwon⁴,Park Chung-Gyu⁵^ORCID,Hong Jinkee⁴^ORCID,Doh Junsang⁶⁷,Lee Dong Yun²^ORCID,Kim Byung-Gee¹⁷⁸^ORCID,Hwang Nathaniel S.¹⁷⁸^ORCID

Affiliation:

1. School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.

2. Department of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Republic of Korea.

3. Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk 37673, Republic of Korea.

4. Department of Chemical and Biomolecular Engineering, College of Engineering, Yonsei University, Seoul 03722, Republic of Korea.

5. Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.

6. Department of Materials Science and Engineering, Research of Advanced Materials (RIAM), Institute of Engineering Research, Seoul National University, Seoul 08826, Republic of Korea.

7. BioMAX/N-Bio Institute, Institute of Bioengineering, Seoul National University, Seoul 08826, Republic of Korea.

8. Interdisciplinary Program in Bioengineering, Seoul National University, Seoul 08826, Republic of Korea.

Abstract

A multilayer hydrogel nanofilm on the cell surface via enzymatic reactions provides a new platform for β cell–based therapy.

Funder

FP7 Information and Communication Technologies

Korea Health Industry Development Institute

National Research Foundation of Korea

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary