Green/red light-sensing mechanism in the chromatic acclimation photosensor

Author:

Nagae Takayuki1ORCID,Fujita Yuya2ORCID,Tsuchida Tatsuya3,Kamo Takanari2,Seto Ryoka4,Hamada Masako2,Aoyama Hiroshi1ORCID,Sato-Tomita Ayana5ORCID,Fujisawa Tomotsumi4ORCID,Eki Toshihiko2,Miyanoiri Yohei6ORCID,Ito Yutaka7ORCID,Soeta Takahiro3,Ukaji Yutaka3,Unno Masashi4ORCID,Mishima Masaki1ORCID,Hirose Yuu2ORCID

Affiliation:

1. Department of Molecular Biophysics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan.

2. Department of Applied Chemistry and Life Science, Toyohashi University of Technology, Toyohashi, Aichi 441-8580, Japan.

3. Division of Material Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan.

4. Department of Chemistry and Applied Chemistry, Faculty of Science and Engineering, Saga University, Honjomachi, Saga 840-8502, Japan.

5. Division of Biophysics, Department of Physiology, Jichi Medical University, Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.

6. Institute for Protein Research, Osaka University, Suita, Osaka 565-0871, Japan.

7. Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Hachioji, Tokyo 192-0397, Japan.

Abstract

Certain cyanobacteria alter their photosynthetic light absorption between green and red, a phenomenon called complementary chromatic acclimation. The acclimation is regulated by a cyanobacteriochrome-class photosensor that reversibly photoconverts between green-absorbing (Pg) and red-absorbing (Pr) states. Here, we elucidated the structural basis of the green/red photocycle. In the Pg state, the bilin chromophore adopted the extended C15- Z , anti structure within a hydrophobic pocket. Upon photoconversion to the Pr state, the bilin is isomerized to the cyclic C15- E , syn structure, forming a water channel in the pocket. The solvation/desolvation of the bilin causes changes in the protonation state and the stability of π-conjugation at the B ring, leading to a large absorption shift. These results advance our understanding of the enormous spectral diversity of the phytochrome superfamily.

Publisher

American Association for the Advancement of Science (AAAS)

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