3D bioprinting spatiotemporally defined patterns of growth factors to tightly control tissue regeneration

Author:

Freeman Fiona E.12ORCID,Pitacco Pierluca12,van Dommelen Lieke H. A.3ORCID,Nulty Jessica12ORCID,Browe David C.12ORCID,Shin Jung-Youn4,Alsberg Eben45ORCID,Kelly Daniel J.1267ORCID

Affiliation:

1. Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland.

2. Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, Ireland.

3. Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.

4. Departments of Biomedical Engineering and Orthopaedic Surgery, Case Western Reserve University, Cleveland, OH 44106, USA.

5. Departments of Biomedical Engineering, Pharmacology, Orthopaedics, and Mechanical and Industrial Engineering, University of Illinois at Chicago, Chicago, IL 60607, USA.

6. Department of Anatomy, Royal College of Surgeons in Ireland, Dublin, Ireland.

7. Advanced Materials and Bioengineering Research Centre (AMBER), Royal College of Surgeons in Ireland and Trinity College Dublin, Dublin, Ireland.

Abstract

Spatiotemporal delivery of VEGF and BMP-2 from 3D bioprinted implants enhances angiogenesis and subsequent bone regeneration.

Funder

European Research Council

Irish Research Council

National Institutes of Health NIAMS

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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