The prostate cancer risk variant rs55958994 regulates multiple gene expression through extreme long-range chromatin interaction to control tumor progression-Reference-Cited by-同舟云学术

The prostate cancer risk variant rs55958994 regulates multiple gene expression through extreme long-range chromatin interaction to control tumor progression

Published:2019-07-05 Issue:7 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Qian Yuyang¹^ORCID,Zhang Lei¹^ORCID,Cai Mingyang²,Li Hongxia¹,Xu Heming¹,Yang Hongzhen¹^ORCID,Zhao Zhongfang¹,Rhie Suhn Kyong³^ORCID,Farnham Peggy J.³^ORCID,Shi Jiandang¹^ORCID,Lu Wange²^ORCID

Affiliation:

1. State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, 94 Weijin Road, 300071 Tianjin, China.

2. Department of Stem Cell Biology and Regenerative Medicine, Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

3. Department of Biochemistry and Molecular Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

Abstract

The rs55958994-associated enhancer regulates prostate cancer progression by long-range regulation of multiple target genes.

Funder

National Institutes of Health

National Natural Science Foundation of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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