Targeted disruption of Kv2.1-VAPA association provides neuroprotection against ischemic stroke in mice by declustering Kv2.1 channels-Reference-Cited by-同舟云学术

Targeted disruption of Kv2.1-VAPA association provides neuroprotection against ischemic stroke in mice by declustering Kv2.1 channels

Published:2020-07-03 Issue:27 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Schulien Anthony J.¹²^ORCID,Yeh Chung-Yang¹²^ORCID,Orange Bailey N.¹²^ORCID,Pav Olivia J.¹²^ORCID,Hopkins Madelynn P.¹²^ORCID,Moutal Aubin³^ORCID,Khanna Rajesh³^ORCID,Sun Dandan²⁴^ORCID,Justice Jason A.¹²^ORCID,Aizenman Elias¹²^ORCID

Affiliation:

1. Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

2. Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

3. Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA.

4. Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Abstract

A neuroprotective peptide protects mice against ischemic stroke injury by disrupting Kv2.1 potassium channel clusters in neurons.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference50 articles.

1. CDC Grand Rounds: Public Health Strategies to Prevent and Treat Strokes

2. Apoptotic Mechanisms After Cerebral Ischemia

3. Mediation of Neuronal Apoptosis by Kv2.1-Encoded Potassium Channels

4. Identification of the Kv2.1 K+Channel as a Major Component of the Delayed Rectifier K+Current in Rat Hippocampal Neurons

5. Kv2 channels regulate firing rate in pyramidal neurons from rat sensorimotor cortex

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