Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in nonhuman primates-Reference-Cited by-同舟云学术

Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in nonhuman primates

Published:2020-05-15 Issue:20 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Bourdenx M.¹²^ORCID,Nioche A.¹²³⁴^ORCID,Dovero S.¹²^ORCID,Arotcarena M.-L.¹²^ORCID,Camus S.¹²,Porras G.¹²^ORCID,Thiolat M.-L.¹²^ORCID,Rougier N. P.¹²⁵^ORCID,Prigent A.⁶⁷⁸^ORCID,Aubert P.⁶⁷⁸,Bohic S.⁹^ORCID,Sandt C.¹⁰^ORCID,Laferrière F.¹²^ORCID,Doudnikoff E.¹²,Kruse N.¹¹¹²,Mollenhauer B.¹¹¹²,Novello S.¹³¹⁴^ORCID,Morari M.¹³¹⁴^ORCID,Leste-Lasserre T.¹⁵^ORCID,Trigo-Damas I.¹⁶¹⁷,Goillandeau M.¹²,Perier C.¹⁷¹⁸^ORCID,Estrada C.¹⁹²⁰,Garcia-Carrillo N.²¹,Recasens A.¹⁷¹⁸^ORCID,Vaikath N. N.²²^ORCID,El-Agnaf O. M. A.²²,Herrero M. T.¹⁹²⁰,Derkinderen P.⁶⁷⁸,Vila M.¹⁷¹⁸²³²⁴^ORCID,Obeso J. A.¹⁶¹⁷,Dehay B.¹²^ORCID,Bezard E.¹²^ORCID

Affiliation:

1. Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.

2. CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.

3. Institut Jean Nicod, Département d’études cognitives, ENS, EHESS, PSL Research University, 75005 Paris, France.

4. Institut Jean Nicod, Département d’études cognitives, CNRS, UMR 8129, Paris, France.

5. INRIA Bordeaux Sud-Ouest, 33405 Talence, France.

6. INSERM, U1235, Nantes F-44035, France.

7. Nantes University, Nantes F-44035, France.

8. CHU Nantes, Department of Neurology, Nantes F-44093, France.

9. EA-7442 Rayonnement Synchrotron et Recherche Medicale, RSRM, University of Grenoble Alpes, 38000 Grenoble, France.

10. SMIS beamline, Synchrotron SOLEIL, l’orme des merisiers, 91192 Gif sur Yvette, France.

11. Paracelsus-Elena-Klinik, Kassel, Germany.

12. University Medical Center Goettingen, Institute of Neuropathology, Goettingen, Germany.

13. Department of Medical Sciences, Section of Pharmacology, University of Ferrara, via Fossato di Mortara 17-19, 44121 Ferrara, Italy.

14. Neuroscience Center and National Institute of Neuroscience, University of Ferrara, via Fossato di Mortara 17-19, 44121 Ferrara, Italy.

15. INSERM, Neurocentre Magendie, U1215, Physiopathologie de la Plasticité Neuronale, F-33000 Bordeaux, France.

16. HM CINAC, HM Puerta del Sur and CEU–San Pablo University Madrid, E-28938 Mostoles, Spain.

17. Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Instituto Carlos III, Madrid, Spain.

18. Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)–Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Barcelona, Spain.

19. Clinical and Experimental Neuroscience Unit, School of Medicine, Biomedical Research Institute of Murcia (IMIB), University of Murcia, Campus Mare Nostrum, 30100 Murcia, Spain.

20. Institute of Research on Aging (IUIE), School of Medicine, University of Murcia, 30100 Murcia, Spain.

21. Centro Experimental en Investigaciones Biomédica (CEIB), Universidad de Murcia, Murcia, Spain.

22. Neurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Education City, Qatar.

23. Department of Biochemistry and Molecular Biology, Autonomous University of Barcelona (UAB), Barcelona, Spain.

24. Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain.

Abstract

Machine learning–based approach unravels distinct pathological signatures induced by patient-derived α-synuclein seeds in monkeys.

Funder

Michael J. Fox Foundation for Parkinson’s Research

Fundación Séneca

Ministère de l’Enseignement Supérieur et de la Recherche Scientifique

Agence Nationale de la Recherche

Fundacion de Investigacion HM Hospitales

Simone and Cino Del Duca Prize

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference60 articles.

1. Staging of brain pathology related to sporadic Parkinson’s disease

2. Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

3. Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

4. Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years

5. Alpha-synuclein propagation: New insights from animal models

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