Research Priorities on the Role of α‐<scp>Synuclein</scp> in Parkinson's Disease Pathogenesis-Reference-Cited by-同舟云学术

Research Priorities on the Role of α‐Synuclein in Parkinson's Disease Pathogenesis

Published:2024-06-30 Issue: Volume: Page:
ISSN:0885-3185
Container-title:Movement Disorders
language:en
Short-container-title:Movement Disorders

Author:

Burré Jacqueline¹^ORCID,Edwards Robert H.²^ORCID,Halliday Glenda³^ORCID,Lang Anthony E.⁴⁵^ORCID,Lashuel Hilal A.⁶,Melki Ronald⁷,Murayama Shigeo⁸⁹,Outeiro Tiago F.¹⁰¹¹^ORCID,Papa Stella M.¹²^ORCID,Stefanis Leonidas¹³¹⁴^ORCID,Woerman Amanda L.¹⁵¹⁶^ORCID,Surmeier Dalton James¹⁷¹⁸^ORCID,Kalia Lorraine V.⁴⁵^ORCID,Takahashi Ryosuke¹⁹^ORCID,

Affiliation:

1. Appel Institute for Alzheimer's Disease Research and Brain and Mind Research Institute, Weill Cornell Medicine New York New York USA

2. Department of Physiology and Neurology University of California, San Francisco School of Medicine San Francisco California USA

3. Brain and Mind Centre, School of Medical Sciences, The University of Sydney Camperdown New South Wales Australia

4. Edmond J. Safra Program in Parkinson's Disease, Krembil Research Institute, Toronto Western Hospital, University Health Network Toronto Ontario Canada

5. Division of Neurology, Department of Medicine University of Toronto Toronto Ontario Canada

6. Laboratory of Chemical Biology of Neurodegeneration, Brain Mind Institute, École Polytechnique Fédérale de Lausanne (EPFL) Lausanne Switzerland

7. Institut Francois Jacob (MIRCen), CEA and Laboratory of Neurodegenerative Diseases, CNRS Fontenay‐Aux‐Roses France

8. Department of Neuropathology Tokyo Metropolitan Institute for Geriatrics and Gerontology Tokyo Japan

9. The Brain Bank for Neurodevelopmental, Neurological and Psychiatric Disorders, United Graduate School of Child Development Osaka University Osaka Japan

10. Department of Experimental Neurodegeneration University Medical Center Göttingen Germany

11. Faculty of Medical Sciences, Translational and Clinical Research Institute Newcastle University Newcastle upon Tyne United Kingdom

12. Department of Neurology School of Medicine, and Emory National Primate Research Center, Emory University Atlanta Georgia USA

13. First Department of Neurology Eginitio Hospital, School of Medicine, National and Kapodistrian University of Athens Athens Greece

14. Biomedical Research Foundation of the Academy of Athens Athens Greece

15. Department of Biology Institute for Applied Life Sciences, University of Massachusetts Amherst Amherst Massachusetts USA

16. Department of Microbiology, Immunology, and Pathology Prion Research Center, Colorado State University Fort Collins Colorado USA

17. Department of Neuroscience, Feinberg School of Medicine Northwestern University Chicago Illinois USA

18. Aligning Science Across Parkinson's (ASAP) Collaborative Research Network Chevy Chase Maryland USA

19. Department of Neurology Graduate School of Medicine, Kyoto University Kyoto Japan

Abstract

AbstractVarious forms of Parkinson's disease, including its common sporadic form, are characterized by prominent α‐synuclein (αSyn) aggregation in affected brain regions. However, the role of αSyn in the pathogenesis and evolution of the disease remains unclear, despite vast research efforts of more than a quarter century. A better understanding of the role of αSyn, either primary or secondary, is critical for developing disease‐modifying therapies. Previous attempts to hone this research have been challenged by experimental limitations, but recent technological advances may facilitate progress. The Scientific Issues Committee of the International Parkinson and Movement Disorder Society (MDS) charged a panel of experts in the field to discuss current scientific priorities and identify research strategies with potential for a breakthrough. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Publisher

Wiley

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