Microneedle-mediated gene delivery for the treatment of ischemic myocardial disease

Author:

Shi Hongpeng1ORCID,Xue Tong2ORCID,Yang Yang3,Jiang Chenyu1ORCID,Huang Shixing1ORCID,Yang Qi1,Lei Dong4,You Zhengwei4,Jin Tuo2,Wu Fei2ORCID,Zhao Qiang1ORCID,Ye Xiaofeng1ORCID

Affiliation:

1. Department of Cardiac Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P. R. China.

2. School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.

3. Department of Cardiothoracic Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, P. R. China.

4. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, International Joint Laboratory for Advanced Fiber and Low-Dimension Materials, College of Materials Science and Engineering Donghua University, Shanghai 201620, P. R. China.

Abstract

Phase transition microneedles provide an optimal administration method for cardiac gene therapy.

Funder

Natural Science Foundation of Shanghai

National Natural Science Foundation of China

Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support

Shanghai Municipal Key Clinical Specialty Construction Project

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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