Nanoparticle–Patch System for Localized, Effective, and Sustained miRNA Administration into Infarcted Myocardium to Alleviate Myocardial Ischemia–Reperfusion Injury

Author:

Chen Xuerui123ORCID,Chen Hang123,Zhu Liyun123,Zeng Mengting123,Wang Tianhui23,Su Chanyuan4,Vulugundam Gururaja5,Gokulnath Priyanka6,Li Guoping6,Wang Xu7,Yao Jianhua8,Li Jin123,Cretoiu Dragos910,Chen Zhaoyang4,Bei Yihua123ORCID

Affiliation:

1. Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People’s Hospital of Nantong) and School of Life Science, Shanghai University, Nantong 226011, China

2. Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), Shanghai University, Shanghai 200444, China

3. Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, Shanghai 200444, China

4. Department of Cardiology, Heart Center of Fujian Province, Fujian Medical University Union Hospital, Fuzhou ,Fujian 350001, China

5. Biologics Development, Sanofi, Framingham, Massachusetts 01701, United States

6. Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, United States

7. Hangzhou Medical College, Binjiang Higher Education Park, Hangzhou 310053, China

8. Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200040, China

9. Department of Medical Genetics, Carol Davila University of Medicine and Pharmacy, Bucharest 050474, Romania

10. Fetal Medicine Excellence Research Center, Alessandrescu-Rusescu National Institute of Mother and Child Health, Bucharest 020395, Romania

Funder

Ministry of Science and Technology of the People's Republic of China

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

Excellent Young Scholars Cultivation Project of Fujian Medical University Union Hospital

Youth Talent Support Program of Fujian Province

Oriental Scholars of Shanghai Universities

Publisher

American Chemical Society (ACS)

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