Asymmetry in catalysis by Thermotoga maritima membrane-bound pyrophosphatase demonstrated by a nonphosphorus allosteric inhibitor-Reference-Cited by-同舟云学术

Asymmetry in catalysis by Thermotoga maritima membrane-bound pyrophosphatase demonstrated by a nonphosphorus allosteric inhibitor

Published:2019-05-03 Issue:5 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Vidilaseris Keni¹^ORCID,Kiriazis Alexandros²,Turku Ainoleena²^ORCID,Khattab Ayman³,Johansson Niklas G.²^ORCID,Leino Teppo O.²^ORCID,Kiuru Paula S.²^ORCID,Boije af Gennäs Gustav²^ORCID,Meri Seppo³,Yli-Kauhaluoma Jari²^ORCID,Xhaard Henri²^ORCID,Goldman Adrian¹⁴^ORCID

Affiliation:

1. Research Program in Molecular and Integrative Biosciences, University of Helsinki, Helsinki, Finland.

2. Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.

3. Malaria Research Laboratory, Immunobiology Research Program, Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland.

4. School of Biomedical Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK.

Abstract

Novel inhibitors of membrane-bound pyrophosphatases unlock asymmetric conformations by binding near the exit channel.

Funder

BBSRC

Academy of Finland

The Jane and Aatos Erkko Foundation

University of Helsinki funds

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary