Pyrophosphate-Fueled Na + and H + Transport in Prokaryotes

Author:

Baykov Alexander A.1,Malinen Anssi M.2,Luoto Heidi H.2,Lahti Reijo2

Affiliation:

1. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia

2. Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland

Abstract

SUMMARY In its early history, life appeared to depend on pyrophosphate rather than ATP as the source of energy. Ancient membrane pyrophosphatases that couple pyrophosphate hydrolysis to active H + transport across biological membranes (H + -pyrophosphatases) have long been known in prokaryotes, plants, and protists. Recent studies have identified two evolutionarily related and widespread prokaryotic relics that can pump Na + (Na + -pyrophosphatase) or both Na + and H + (Na + ,H + -pyrophosphatase). Both these transporters require Na + for pyrophosphate hydrolysis and are further activated by K + . The determination of the three-dimensional structures of H + - and Na + -pyrophosphatases has been another recent breakthrough in the studies of these cation pumps. Structural and functional studies have highlighted the major determinants of the cation specificities of membrane pyrophosphatases and their potential use in constructing transgenic stress-resistant organisms.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology,Infectious Diseases

Reference75 articles.

1. BaltscheffskyH. 1996. Energy conversion leading to the origin and early evolution of life: did inorganic pyrophosphate precede adenosine triphosphate?, p 1–9. In BaltscheffskyH (ed), Origin and evolution of biological energy conversion. VCH, New York, NY.

2. Links between hydrothermal environments, pyrophosphate, Na+, and early evolution;Holm NG;Orig. Life Evol. Biosph,2011

3. Biological Role of Inorganic Pyrophosphate

4. Evolution of vacuolar proton pyrophosphatase domains and volutin granules: clues into the early evolutionary origin of the acidocalcisome

5. Inorganic pyrophosphate: formation in bacterial photophosphorylation;Baltscheffsky H;Science,1966

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3