Adolescence is a sensitive period for prefrontal microglia to act on cognitive development-Reference-Cited by-同舟云学术

Adolescence is a sensitive period for prefrontal microglia to act on cognitive development

Published:2022-03-04 Issue:9 Volume:8 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Schalbetter Sina M.¹^ORCID,von Arx Anina S.¹,Cruz-Ochoa Natalia²^ORCID,Dawson Kara¹^ORCID,Ivanov Andranik³,Mueller Flavia S.¹,Lin Han-Yu¹^ORCID,Amport René¹,Mildenberger Wiebke⁴,Mattei Daniele¹⁵,Beule Dieter³⁶^ORCID,Földy Csaba²⁷,Greter Melanie⁴^ORCID,Notter Tina¹⁸,Meyer Urs¹⁷^ORCID

Affiliation:

1. Institute of Pharmacology and Toxicology, University of Zürich-Vetsuisse, Zürich, Switzerland.

2. Laboratory of Neural Connectivity, Faculties of Medicine and Natural Sciences, Brain Research Institute, University of Zürich, Zürich, Switzerland.

3. Core Unit Bioinformatics, Berlin Institute of Health, Charité-Universitaetsmedizin, Berlin, Germany.

4. Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.

5. Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

6. Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.

7. Neuroscience Center Zürich, Zürich, Switzerland.

8. Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, Wales, UK.

Abstract

The prefrontal cortex (PFC) is a cortical brain region that regulates various cognitive functions. One distinctive feature of the PFC is its protracted adolescent maturation, which is necessary for acquiring mature cognitive abilities in adulthood. Here, we show that microglia, the brain’s resident immune cells, contribute to this maturational process. We find that transient and cell-specific deficiency of prefrontal microglia in adolescence is sufficient to induce an adult emergence of PFC-associated impairments in cognitive functions, dendritic complexity, and synaptic structures. While prefrontal microglia deficiency in adolescence also altered the excitatory-inhibitory balance in adult prefrontal circuits, there were no cognitive sequelae when prefrontal microglia were depleted in adulthood. Thus, our findings identify adolescence as a sensitive period for prefrontal microglia to act on cognitive development.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference70 articles.

1. The Architecture of Cognitive Control in the Human Prefrontal Cortex

2. What constitutes the prefrontal cortex?

3. Mechanisms contributing to prefrontal cortex maturation during adolescence

4. Prefrontal Cortex Development in Health and Disease: Lessons from Rodents and Humans

5. Adolescence as a neurobiological critical period for the development of higher-order cognition

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