VapBC22 toxin-antitoxin system from Mycobacterium tuberculosis is required for pathogenesis and modulation of host immune response

Author:

Agarwal Sakshi1ORCID,Sharma Arun1ORCID,Bouzeyen Rania2ORCID,Deep Amar3ORCID,Sharma Harsh4ORCID,Mangalaparthi Kiran K.5ORCID,Datta Keshava K.5ORCID,Kidwai Saqib1ORCID,Gowda Harsha56ORCID,Varadarajan Raghavan7ORCID,Sharma Ravi Datta4ORCID,Thakur Krishan Gopal3ORCID,Singh Ramandeep1ORCID

Affiliation:

1. Tuberculosis Research Laboratory, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Harya na-121001, India.

2. Institut Pasteur de Tunis, LTCII, LR11IPT02, Tunis 1002, Tunisia.

3. Structural Biology Laboratory, Council of Scientific and Industrial Research–Institute of Microbial Technology, Chandigarh 160036, India.

4. Amity Institute of Integrative Sciences and Health, Amity University Haryana, Manesar, Gurugr am-122413, India.

5. Institute of Bioinformatics, Bangalore 560066, India.

6. Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore 575018, India.

7. Indian Institute of Science, Bangalore 560012, India.

Abstract

The VapBC22 toxin-antitoxin system regulates adaptation to oxidative stress and virulence in Mycobacterium tuberculosis .

Funder

Department of Biotechnology , Ministry of Science and Technology

Department of Science and Technology, Ministry of Science and Technology

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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