BioBits™ Explorer: A modular synthetic biology education kit

Author:

Huang Ally123ORCID,Nguyen Peter Q.34ORCID,Stark Jessica C.567ORCID,Takahashi Melissa K.2ORCID,Donghia Nina3ORCID,Ferrante Tom3,Dy Aaron J.1289ORCID,Hsu Karen J.10,Dubner Rachel S.11ORCID,Pardee Keith12ORCID,Jewett Michael C.5671314ORCID,Collins James J.12389ORCID

Affiliation:

1. Department of Biological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.

2. Institute for Medical Engineering and Science, MIT, Cambridge, MA 02139, USA.

3. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

4. School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

5. Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208, USA.

6. Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60208, USA.

7. Center for Synthetic Biology, Northwestern University, Evanston, IL 60208, USA.

8. Synthetic Biology Center, MIT, Cambridge, MA 02139, USA.

9. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

10. Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA.

11. Department of Biological Sciences, Northwestern University, Evanston, IL 60208, USA.

12. Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada.

13. Robert H. Lurie Comprehensive Cancer Center, Northwestern University, 676 North Saint Clair Street, Suite 1200, Chicago, IL 60611, USA.

14. Simpson Querrey Institute, Northwestern University, Chicago, IL 60611, USA.

Abstract

We present a low-cost kit based on freeze-dried, cell-free reactions to illustrate synthetic and molecular biology concepts.

Funder

National Science Foundation

David and Lucile Packard Foundation

Air Force Office of Scientific Research

Army Research Office

Wyss institute

Paul G. Allen Frontiers Group

Air Force Research Laboratory Center of Excellence Grant

Defense Threat Reduction Agency Grant

Camille Dreyfus Teacher-Scholar Program

Natural Sciences and Engineering Council of Canada

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference52 articles.

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3. Digital games, design, and learning: A systematic review and meta-analysis;Clark D. B.;Rev. Educ. Res.,2016

4. National Research Council Next Generation Science Standards: For States By States (National Academies Press 2013).

5. Active learning increases student performance in science, engineering, and mathematics;Freeman S.;Proc. Natl. Acad. Sci. U.S.A.,2014

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