A 3D human brain–like tissue model of herpes-induced Alzheimer’s disease-Reference-Cited by-同舟云学术

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A 3D human brain–like tissue model of herpes-induced Alzheimer’s disease

Published:2020-05-08 Issue:19 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Cairns Dana M.¹²^ORCID,Rouleau Nicolas¹²,Parker Rachael N.¹,Walsh Katherine G.³^ORCID,Gehrke Lee⁴^ORCID,Kaplan David L.¹²^ORCID

Affiliation:

1. Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.

2. Allen Discovery Center, Tufts University, Medford, MA 02155, USA.

3. Department of Biology, Tufts University, Medford, MA 02155, USA.

4. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

Abstract

In vitro 3D human brain–like cultures infected with herpes virus develop Alzheimer’s disease characteristics.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference60 articles.

1. 2016 Alzheimer's disease facts and figures

2. Genomic variants, genes, and pathways of Alzheimer's disease: An overview

3. APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP

4. Presenilin-1 mutations and Alzheimer’s disease

5. The secretases: enzymes with therapeutic potential in Alzheimer disease

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