APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP

Author:

Weyer Sascha W1,Klevanski Maja1,Delekate Andrea2,Voikar Vootele3,Aydin Dorothee1,Hick Meike1,Filippov Mikhail1,Drost Natalia1,Schaller Kristin L4,Saar Martina1,Vogt Miriam A5,Gass Peter6,Samanta Ayan7,Jäschke Andres7,Korte Martin2,Wolfer David P36,Caldwell John H4,Müller Ulrike C1

Affiliation:

1. Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, Heidelberg University; Heidelberg Germany

2. Cellular Neurobiology, Zoological Institute, TU Braunschweig; Braunschweig Germany

3. Institute of Anatomy and Zurich Center for Integrative Human Physiology, University of Zurich; Zurich Switzerland

4. Department of Cell and Developmental Biology, Institute of Physiology and Biophysics, University of Colorado School of Medicine; Aurora CO USA

5. Department for Psychiatry and Psychotherapy, Central Institute of Mental Health; Mannheim Germany

6. Department of Biology, Institute of Human Movement Sciences, ETH Zurich; Zurich Switzerland

7. Department of Pharmaceutical Chemistry, Institute of Pharmacy and Molecular Biotechnology, Heidelberg University; Heidelberg Germany

Publisher

Wiley

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

Reference54 articles.

1. The functions of mammalian amyloid precursor protein and related amyloid precursor-like proteins;Anliker;Neurodegener Dis,2006

2. Fasciclin II signals new synapse formation through amyloid precursor protein and the scaffolding protein dX11/Mint;Ashley;J Neurosci,2005

3. Neurons generated from APP/APLP1/APLP2 triple knockout embryonic stem cells behave normally in vitro and in vivo: lack of evidence for a cell autonomous role of the amyloid precursor protein in neuronal differentiation;Bergmans;Stem Cells,2010

4. A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60;Cao;Science,2001

5. Cognitive functions of hippocampus lesioned mice assessed in the IntelliCage;Colacicco;Neuroscience Meeting Planner Society for Neuroscience,2009

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