Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid–induced differentiation-Reference-Cited by-同舟云学术

Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid–induced differentiation

Published:2020-04-10 Issue:15 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Ravasio Roberto¹^ORCID,Ceccacci Elena¹,Nicosia Luciano¹^ORCID,Hosseini Amir¹^ORCID,Rossi Pier Luigi¹^ORCID,Barozzi Iros²^ORCID,Fornasari Lorenzo¹³,Zuffo Roberto Dal⁴,Valente Sergio⁵^ORCID,Fioravanti Rossella⁵^ORCID,Mercurio Ciro⁴,Varasi Mario⁴,Mattevi Andrea⁶^ORCID,Mai Antonello⁵^ORCID,Pavesi Giulio⁷^ORCID,Bonaldi Tiziana¹^ORCID,Minucci Saverio¹⁷⁸^ORCID

Affiliation:

1. Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Via Adamello 16, Milan 20139, Italy.

2. Department of Surgery and Cancer, Imperial College London, Hammersmith, London W12, UK.

3. EryDel SpA, Via Meucci 3, 20091 Bresso (MI), Italy.

4. Experimental Therapeutics Program, FIRC Institute of Molecular Oncology Foundation (IFOM), Via Adamello 16, Milan 20139, Italy.

5. Department of Drug Chemistry and Technologies, Pasteur Institute Italy, Cenci Bolognetti Foundation, Sapienza University of Rome, Rome, Italy.

6. Department of Biology and Biotechnology, University of Pavia, Via Ferrata 9, 27100 Pavia, Italy.

7. Department of Biosciences, University of Milan, Milan 20133, Italy.

8. New Drugs Program, European Institute of Oncology (IEO), IRCCS, Milan 20139, Italy.

Abstract

The study addresses the mechanism through which inhibition of LSD1 sensitizes AML cells to retinoic acid–induced differentiation.

Funder

Ministero della Salute

Ministero dell’Istruzione, dell’Università e della Ricerca

Consiglio Nazionale delle Ricerche

Associazione Italiana per la Ricerca sul Cancro

TRANSCAN DRAMA

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference47 articles.

1. Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1

2. Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process

3. Lysine-Specific Demethylase 1 Regulates the Embryonic Transcriptome and CoREST Stability

4. Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation

5. Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation

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