MON-2, a Golgi protein, mediates autophagy-dependent longevity in Caenorhabditis elegans-Reference-Cited by-同舟云学术

MON-2, a Golgi protein, mediates autophagy-dependent longevity in Caenorhabditis elegans

Published:2021-12-03 Issue:49 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Jung Yoonji¹^ORCID,Artan Murat²^ORCID,Kim Nari²^ORCID,Yeom Jeonghun³^ORCID,Hwang Ara B.²^ORCID,Jeong Dae-Eun²,Altintas Özlem²,Seo Keunhee²^ORCID,Seo Mihwa²,Lee Dongyeop²^ORCID,Hwang Wooseon²^ORCID,Lee Yujin¹,Sohn Jooyeon¹^ORCID,Kim Eun Ji E.¹,Ju Sungeun²^ORCID,Han Seong Kyu²,Nam Hyun-Jun²^ORCID,Adams Linnea⁴,Ryu Youngjae⁵,Moon Dong Jin²^ORCID,Kang Chanhee⁶^ORCID,Yoo Joo-Yeon²^ORCID,Park Sang Ki²^ORCID,Ha Chang Man⁵,Hansen Malene⁴,Kim Sanguk²^ORCID,Lee Cheolju³^ORCID,Park Seung-Yeol²^ORCID,Lee Seung-Jae V.¹^ORCID

Affiliation:

1. Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, South Korea.

2. Department of Life Sciences, Pohang University of Science and Technology, 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk 37673, South Korea.

3. Center for Theragnosis, Korea Institute of Science and Technology, Seoul 02792, South Korea.

4. Development, Aging, and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

5. Research Division and Brain Research Core Facilities of Korea Brain Research Institute, Daegu 41068, South Korea.

6. School of Biological Sciences, College of Natural Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, South Korea.

Abstract

MON-2, which mediates Golgi-endosome trafficking, mediates mitochondrial inhibition–induced longevity by enhancing autophagy.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference77 articles.

1. Membrane Traffic Within the Golgi Apparatus

2. Passage through the Golgi

3. Identification of yeast deletion strains that are hypersensitive to brefeldin A or monensin, two drugs that affect intracellular transport

4. Yeast Mon2p is a highly conserved protein that functions in the cytoplasm-to-vacuole transport pathway and is required for Golgi homeostasis

5. Mon2, a Relative of Large Arf Exchange Factors, Recruits Dop1 to the Golgi Apparatus

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