Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain-Reference-Cited by-同舟云学术

Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain

Published:2019-06-07 Issue:6 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Richner Mette¹²^ORCID,Pallesen Lone T.¹²^ORCID,Ulrichsen Maj¹²^ORCID,Poulsen Ebbe T.³^ORCID,Holm Thomas H.²^ORCID,Login Hande²,Castonguay Annie⁴⁵^ORCID,Lorenzo Louis-Etienne⁴⁵^ORCID,Gonçalves Nádia P.²,Andersen Olav M.¹²^ORCID,Lykke-Hartmann Karin²^ORCID,Enghild Jan J.³^ORCID,Rønn Lars C. B.⁶,Malik Ibrahim J.⁶,De Koninck Yves⁴⁵^ORCID,Bjerrum Ole J.⁷,Vægter Christian B.¹²^ORCID,Nykjær Anders¹²⁸⁹

Affiliation:

1. The Lundbeck Foundation Research Center MIND, Department of Biomedicine, Aarhus University, Denmark.

2. Danish Research Institute of Translational Neuroscience (DANDRITE)–Nordic EMBL Partnership for Molecular Medicine, Department of Biomedicine, Aarhus University, Denmark.

3. Department of Molecular Biology and Genetics, Aarhus University, Denmark.

4. CERVO Brain Research Centre, Québec Mental Health Institute, Québec, QC, Canada.

5. Department of Psychiatry and Neuroscience, Université Laval, Québec, QC, Canada.

6. Neurodegeneration Disease Biology Unit, H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark.

7. Department of Drug Design and Pharmacology, University of Copenhagen, Denmark.

8. The Danish National Research Foundation Center, PROMEMO, Department of Biomedicine, Aarhus University, Aarhus, Denmark.

9. Department of Neurosurgery, Aarhus University Hospital, Aarhus, Denmark.

Abstract

Blocking of sortilin ligand binding prevents neuropathic pain by inhibiting BDNF-induced spinal KCC2 down-regulation.

Funder

European Commission Directorate-General for Research and Innovation

Dagmar Marshalls Fond

Canadian Institutes of Health Research

Danish National Research Foundation

Lundbeckfonden

Carlsbergfondet

Aase og Ejnar Danielsens Fond

Simon Fougner Hartmanns Familiefond

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference46 articles.

1. Neuropathic pain in the general population: A systematic review of epidemiological studies

2. Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain

3. Spinal cord injury-induced attenuation of GABAergic inhibition in spinal dorsal horn circuits is associated with down-regulation of the chloride transporter KCC2 in rat;Lu Y.;J. Physiol.,2008

4. Chloride Regulation: A Dynamic Equilibrium Crucial for Synaptic Inhibition

5. BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain

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