Single-cell transcriptome of early hematopoiesis guides arterial endothelial-enhanced functional T cell generation from human PSCs-Reference-Cited by-同舟云学术

Single-cell transcriptome of early hematopoiesis guides arterial endothelial-enhanced functional T cell generation from human PSCs

Published:2021-09-03 Issue:36 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Shen Jun¹^ORCID,Xu Yingxi¹²^ORCID,Zhang Shuo¹^ORCID,Lyu Shuzhen¹^ORCID,Huo Yingying¹^ORCID,Zhu Yaoyao¹³,Tang Kejing¹²,Mou Junli¹²^ORCID,Li Xinjie⁴^ORCID,Hoyle Dixie L.⁵,Wang Min¹²^ORCID,Wang Jianxiang¹⁶^ORCID,Li Xin⁴^ORCID,Wang Zack Z.⁵^ORCID,Cheng Tao¹⁷⁸^ORCID

Affiliation:

1. State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China.

2. Tianjin Key Laboratory of Blood Disease Cell Therapy, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China.

3. Department of Laboratory, The Second Hospital of Tianjin Medical University, Tianjin 300211, China.

4. School of Medicine, Sun Yat-sen University, Guangzhou 510006, China.

5. Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

6. National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin 300020, China.

7. Center for Stem Cell Medicine, Chinese Academy of Medical Sciences, Tianjin 300020, China.

8. Department of Stem Cell and Regenerative Medicine, Peking Union Medical College, Tianjin 300020, China.

Abstract

Hypoxia enhances hematopoiesis with functional T cell potential from human pluripotent stem cells via arterial priming.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference59 articles.

1. Human‐induced pluripotent stem cell‐derived blood products: state of the art and future directions

2. Haematopoietic stem and progenitor cells from human pluripotent stem cells

3. Mouse extraembryonic arterial vessels harbor precursors capable of maturing into definitive HSCs