Combinatorial screening of biochemical and physical signals for phenotypic regulation of stem cell–based cartilage tissue engineering

Author:

Lee Junmin123ORCID,Jeon Oju45ORCID,Kong Ming678,Abdeen Amr A.9ORCID,Shin Jung-Youn4,Lee Ha Neul10,Lee Yu Bin45ORCID,Sun Wujin123ORCID,Bandaru Praveen123ORCID,Alt Daniel S.45ORCID,Lee KangJu123,Kim Han-Jun123ORCID,Lee Sang Jin45ORCID,Chaterji Somali1112ORCID,Shin Su Ryon78ORCID,Alsberg Eben45131415ORCID,Khademhosseini Ali12378ORCID

Affiliation:

1. Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA.

2. Center for Minimally Invasive Therapeutics (C-MIT), University of California, Los Angeles, Los Angeles, CA 90095, USA.

3. California NanoSystems Institute (CNSI), University of California, Los Angeles, Los Angeles, CA 90095, USA.

4. Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.

5. Department of Bioengineering, University of Illinois-Chicago, Chicago, IL 60607, USA.

6. College of Marine Life Science, Ocean University of China, Yushan Road, Qingdao, Shandong Province 266003, China.

7. Department of Medicine, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.

8. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

9. Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA.

10. Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.

11. Agricultural and Biological Engineering, Purdue University, West Lafayette, IN 47907, USA.

12. Center for Resilient Infrastructures, Systems, and Processes (CRISP), Purdue University, West Lafayette, IN 47907, USA.

13. Department of Orthopaedics, University of Illinois-Chicago, Chicago, IL 60612, USA.

14. Department of Orthopaedic Surgery, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.

15. National Center for Regenerative Medicine, Division of General Medical Sciences, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.

Abstract

Multicomponent biomaterials using a high-throughput system regulate hyaline or hypertrophic chondrogenesis of hMSCs.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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