Unlike Bone, Cartilage Regeneration Remains Elusive

Author:

Huey Daniel J.1,Hu Jerry C.1,Athanasiou Kyriacos A.1

Affiliation:

1. Department of Biomedical Engineering, University of California, Davis, 1 Shields Avenue, Davis, CA 95616, USA.

Abstract

Articular cartilage was predicted to be one of the first tissues to successfully be regenerated, but this proved incorrect. In contrast, bone (but also vasculature and cardiac tissues) has seen numerous successful reparative approaches, despite consisting of multiple cell and tissue types and, thus, possessing more complex design requirements. Here, we use bone-regeneration successes to highlight cartilage-regeneration challenges: such as selecting appropriate cell sources and scaffolds, creating biomechanically suitable tissues, and integrating to native tissue. We also discuss technologies that can address the hurdles of engineering a tissue possessing mechanical properties that are unmatched in human-made materials and functioning in environments unfavorable to neotissue growth.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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3. Articular cartilage tissue engineering;Athanasiou K. A.;Synth. Lect. Tissue Eng.,2009

4. U. Meyer H. P. Wiesmann in Bone and Cartilage Engineering (Springer Berlin New York 2006) pp. 20 33 167.

5. Identification and Clonal Characterisation of a Progenitor Cell Sub-Population in Normal Human Articular Cartilage

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