Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin with tubulin degradation effect-Reference-Cited by-同舟云学术

Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin with tubulin degradation effect

Published:2021-05-21 Issue:21 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Yang Jianhong¹^ORCID,Yu Yamei¹^ORCID,Li Yong¹^ORCID,Yan Wei¹^ORCID,Ye Haoyu¹,Niu Lu¹,Tang Minghai¹,Wang Zhoufeng²^ORCID,Yang Zhuang¹,Pei Heying¹^ORCID,Wei Haoche¹,Zhao Min¹^ORCID,Wen Jiaolin¹,Yang Linyu¹,Ouyang Liang¹,Wei Yuquan¹,Chen Qiang¹^ORCID,Li Weimin²^ORCID,Chen Lijuan¹^ORCID

Affiliation:

1. Laboratory of Natural and Targeted Small Molecule Drugs, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China.

2. Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.

Abstract

A novel binding site on α-tubulin shows promise as a target for a new generation of anticancer drugs.

Funder

National Natural Science Foundation of China

West China Hospital, Sichuan University

Sichuan Science and Technology Program Grants

Post Doctor Research Project Sichuan University

China Postdoctoral Science Foundation Grants

Publisher

American Association for the Advancement of Science (AAAS)

Subject