Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L-Reference-Cited by-同舟云学术

Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L

Published:2020-12-11 Issue:50 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Sacco Michael Dominic¹^ORCID,Ma Chunlong²^ORCID,Lagarias Panagiotis³,Gao Ang²,Townsend Julia Alma⁴,Meng Xiangzhi⁵,Dube Peter⁵,Zhang Xiujun¹,Hu Yanmei²,Kitamura Naoya²,Hurst Brett⁶⁷^ORCID,Tarbet Bart⁶⁷^ORCID,Marty Michael Thomas⁴^ORCID,Kolocouris Antonios³,Xiang Yan⁵,Chen Yu¹^ORCID,Wang Jun²^ORCID

Affiliation:

1. Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.

2. Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, AZ 85721, USA.

3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens 15771, Greece.

4. Department of Chemistry and Biochemistry, The University of Arizona, Tucson, AZ 85721, USA.

5. Department of Microbiology, Immunology, and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.

6. Institute for Antiviral Research, Utah State University, Logan, UT 84322, USA.

7. Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT 84322, USA.

Abstract

X-ray crystal structures of SARS-CoV-2 M pro with dual inhibitors provide a new direction for the designing of COVID-19 antivirals.

Funder

National Institute of General Medical Sciences

National Institute of Allergy and Infectious Diseases

Arizona Biomedical Research Commission

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary