Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-κB activity

Author:

Miyazaki T.12ORCID,Zhao Z.34,Ichihara Y.56ORCID,Yoshino D.37,Imamura T.6,Sawada K.38,Hayano S.9,Kamioka H.9,Mori S.1,Hirata H.3ORCID,Araki K.3ORCID,Kawauchi K.3ORCID,Shigemoto K.1,Tanaka S.10,Bonewald L. F.11,Honda H.12,Shinohara M.513,Nagao M.5,Ogata T.5ORCID,Harada I.8,Sawada Y.35814ORCID

Affiliation:

1. Department of Geriatric Medicine, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo 173-0015, Japan.

2. Department of Orthopaedic Surgery, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo 173-0015, Japan.

3. Mechanobiology Institute, National University of Singapore, Level 10, T-Lab, 5A Engineering Drive 1, Singapore 117411, Singapore.

4. Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singapore.

5. Department of Rehabilitation for Motor Functions, Research Institute, National Rehabilitation Center for Persons with Disabilities, Tokorozawa, Saitama 359-8555, Japan.

6. Division of Pharmacology, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8503, Japan.

7. Creative Interdisciplinary Research Division, Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Miyagi 980-8578, Japan.

8. Laboratory for Mechanical Medicine, Nadogaya Research Institute, Nadogaya Hospital, Kashiwa, Chiba 277-0032, Japan.

9. Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Okayama 700-8525, Japan.

10. Department of Orthopaedic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.

11. Indiana Center for Musculoskeletal Health, School of Medicine, Indiana University, Indianapolis, IN 46202, USA.

12. Field of Human Disease Models, Institute of Laboratory Animals, Tokyo Women’s Medical University, Tokyo 162-8666, Japan.

13. Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency (JST), Saitama 332-0012, Japan.

14. Department of Clinical Research, National Rehabilitation Center for Persons with Disabilities, Tokorozawa, Saitama 359-8555, Japan.

Abstract

p130Cas translocates into the nucleus upon fluid shear stress application and alleviates NF-κB activity in osteocytes.

Funder

Japan Society for the Promotion of Science

Mechanobiology Institute, Singapore

MEXT-Supported Program for the Strategic Research Foundation at Private Universities

Japanese Society for Musculoskeletal Medicine

Precursory Research for Embryonic Science and Technology

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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