Affiliation:
1. Department of Orthopedics The First Affiliated Hospital of Soochow University Suzhou Jiangsu China
2. Department of Orthopedics Centre for Leading Medicine and Advanced Technologies of IHM Division of Life Sciences and Medicine The First Affiliated Hospital of USTC University of Science and Technology of China Hefei China
3. Department of Orthopedics Jingjiang People's Hospital Seventh Clinical Medical School of Yangzhou University Jingjiang Jiangsu Province China
Abstract
AbstractAs a highly dynamic tissue, bone is continuously rebuilt throughout life. Both bone formation by osteoblasts and bone resorption by osteoclasts constitute bone reconstruction homeostasis. The equilibrium of bone homeostasis is governed by many complicated signaling pathways that weave together to form an intricate network. These pathways coordinate the meticulous processes of bone formation and resorption, ensuring the structural integrity and dynamic vitality of the skeletal system. Dysregulation of the bone homeostatic regulatory signaling network contributes to the development and progression of many skeletal diseases. Significantly, imbalanced bone homeostasis further disrupts the signaling network and triggers a cascade reaction that exacerbates disease progression and engenders a deleterious cycle. Here, we summarize the influence of signaling pathways on bone homeostasis, elucidating the interplay and crosstalk among them. Additionally, we review the mechanisms underpinning bone homeostatic imbalances across diverse disease landscapes, highlighting current and prospective therapeutic targets and clinical drugs. We hope that this review will contribute to a holistic understanding of the signaling pathways and molecular mechanisms sustaining bone homeostasis, which are promising to contribute to further research on bone homeostasis and shed light on the development of targeted drugs.
Funder
National Postdoctoral Program for Innovative Talents
National Natural Science Foundation of China
Natural Science Foundation of Jiangsu Province
Priority Academic Program Development of Jiangsu Higher Education Institutions