Thermostable small-molecule inhibitor of angiogenesis and vascular permeability that suppresses a pERK-FosB/ΔFosB–VCAM-1 axis

Author:

Li Yue1ORCID,Alhendi Ahmad M. N.1,Yeh Mei-Chun1,Elahy Mina1,Santiago Fernando S.1,Deshpande Nandan P.2ORCID,Wu Ben1,Chan Enoch1ORCID,Inam Shafqat1,Prado-Lourenco Leonel1,Marchand Jessica3,Joyce Rohan D.3ORCID,Wilkinson-White Lorna E.4,Raftery Mark J.5ORCID,Zhu Meidong678,Adamson Samuel J.8ORCID,Barnat François9,Viaud-Quentric Karen9,Sockler Jim10,Mackay Joel P.11ORCID,Chang Andrew7812,Mitchell Paul13,Marcuccio Sebastian M.314,Khachigian Levon M.1ORCID

Affiliation:

1. Vascular Biology and Translational Research, School of Medical Sciences and UNSW Medicine, University of New South Wales, Sydney, NSW 2052, Australia.

2. Systems Biology Initiative, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.

3. Advanced Molecular Technologies Pty Ltd, Scoresby, VIC 3179, Australia.

4. Sydney Analytical Core Facility, University of Sydney, NSW 2006, Australia.

5. Bioanalytical Mass Spectrometry Facility, University of New South Wales, Sydney, NSW 2052, Australia.

6. New South Wales Tissue Bank, New South Wales Organ and Tissue Donation Service, South Eastern Sydney Local Health District, Kogarah, NSW 2217, Australia.

7. Save Sight Institute, Discipline of Clinical Ophthalmology and Eye Health, University of Sydney, NSW 2006, Australia.

8. GreenLight Clinical Pty. Ltd., Woolloomooloo, NSW 2011, Australia.

9. Iris Pharma, La Gaude 06610, France.

10. Statistical Operations and Programming, Datapharm Australia Pty. Ltd., Drummoyne, NSW 2047, Australia.

11. School of Life and Environmental Sciences, University of Sydney, NSW 2006, Australia.

12. Sydney Eye Hospital, Sydney NSW 2000 and University of Sydney, NSW 2006, Australia.

13. Centre for Vision Research, Department of Ophthalmology, Westmead Institute for Medical Research, Westmead Hospital, University of Sydney, Westmead, NSW 2145, Australia.

14. La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia.

Abstract

A thermostable drug suppresses a pERK-FosB/ΔFosB-VCAM-1 axis, endothelial activation, angiogenesis, and retinal permeability.

Funder

National Health and Medical Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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