Memory CD8 + T cells mediate early pathogen-specific protection via localized delivery of chemokines and IFNγ to clusters of monocytes

Author:

Boutet Marie1ORCID,Benet Zachary12,Guillen Erik1,Koch Caroline1,M’Homa Soudja Saidi1,Delahaye Fabien34,Fooksman David12,Lauvau Grégoire1ORCID

Affiliation:

1. Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, NY 10461, USA.

2. Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

3. Department of Genetics, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, NY 10461, USA.

4. Institut Pasteur de Lille, UMR1283/8199, 59000 Lille, France.

Abstract

Protection in vaccinated hosts occurs quickly upon pathogen-specific memory CD8 + T cell–mediated activation of myeloid cells.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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