Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia-Reference-Cited by-同舟云学术

Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia

Published:2019-02 Issue:2 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Hablitz Lauren M.¹^ORCID,Vinitsky Hanna S.¹^ORCID,Sun Qian¹,Stæger Frederik Filip²^ORCID,Sigurdsson Björn²^ORCID,Mortensen Kristian N.²^ORCID,Lilius Tuomas O.²³^ORCID,Nedergaard Maiken¹²^ORCID

Affiliation:

1. Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA.

2. Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.

3. Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Abstract

We show that glymphatic influx into the brain occurs in direct proportion to slow cortical activity and inversely to heart rate.

Funder

National Institute on Aging

National Institute of Neurological Disorders and Stroke

Dr. Miriam and Sheldon G. Adelson Medical Research Foundation

Novo Nordisk UK Research Foundation

Lundbeckfonden

Sigrid Juséliuksen Säätiö

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference40 articles.

1. A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β

2. The Glymphatic System: A Beginner’s Guide

3. Aquaporin-4-dependent glymphatic solute transport in the rodent brain

4. The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future

5. Sleep Drives Metabolite Clearance from the Adult Brain

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