Microengineered perfusable 3D-bioprinted glioblastoma model for in vivo mimicry of tumor microenvironment

Author:

Neufeld Lena1ORCID,Yeini Eilam1ORCID,Reisman Noa1ORCID,Shtilerman Yael1ORCID,Ben-Shushan Dikla1ORCID,Pozzi Sabina1ORCID,Madi Asaf2ORCID,Tiram Galia1ORCID,Eldar-Boock Anat1ORCID,Ferber Shiran1,Grossman Rachel3,Ram Zvi3,Satchi-Fainaro Ronit14ORCID

Affiliation:

1. Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

2. Department of Pathology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

3. Department of Neurosurgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

4. Sagol School of Neurosciences, Tel Aviv University, Tel Aviv 69978, Israel.

Abstract

A perfusable vascularized 3D-bioprinted cancer model with stromal cells can be used for personalized therapy and target discovery.

Funder

Israel Cancer Research Fund

European Research Council

Israel Science Foundation

Nancy and Peter Brown friends of The Israel Cancer Association (ICA) USA, in memory of Kenny and Michael Adler

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference70 articles.

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5. Clinical Development Success Rates and Contributing Factors 2011–2020 (BIO QLS Advisors Informa UK Ltd 2021).

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