Acute sleep loss results in tissue-specific alterations in genome-wide DNA methylation state and metabolic fuel utilization in humans-Reference-Cited by-同舟云学术

Acute sleep loss results in tissue-specific alterations in genome-wide DNA methylation state and metabolic fuel utilization in humans

Published:2018-08-03 Issue:8 Volume:4 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Cedernaes Jonathan¹^ORCID,Schönke Milena²^ORCID,Westholm Jakub Orzechowski³^ORCID,Mi Jia⁴⁵,Chibalin Alexander²,Voisin Sarah¹^ORCID,Osler Megan²,Vogel Heike⁶,Hörnaeus Katarina⁴,Dickson Suzanne L.⁷,Lind Sara Bergström⁴^ORCID,Bergquist Jonas⁴⁸⁹,Schiöth Helgi B¹,Zierath Juleen R.²,Benedict Christian¹^ORCID

Affiliation:

1. Department of Neuroscience, Uppsala University, Uppsala, Sweden.

2. Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden.

3. Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.

4. Department of Chemistry–BMC, Uppsala University, Uppsala, Sweden.

5. Medicine and Pharmarcy Research Center, Binzhou Medical University, Yantai, China.

6. Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rehbruecke, Potsdam, Germany.

7. Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

8. Department of Pathology, University of Utah, Salt Lake City, UT 84132, USA.

9. Precision Medicine, Binzhou Medical University, Yantai, China.

Abstract

Simulated shift work uncovers potential tissue mechanisms for metabolic effects attributed to sleep loss and circadian disruption.

Funder

Swedish Research Council Formas

Swedish Research Council for Health, Working Life and Welfare

Swedish Society of Medicine

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary